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In mice, KOR activation reduces synaptic transmission from the lateral amygdala to the BLA and blocks LTP induction in the BLA (Huge et al., 2009)

Considering that liver and gastric cancers are both major diseases that pose a serious threat to peoples health, and there are a large numbers of cancer patients with abnormal expressions of c-Met or NTRK, or simultaneous of them, we believe that as a multi-target kinase inhibitor, 1D228 will play an significant role in the treatment of the aforementioned cancer patients after it is approved